A Laboratory Manual of Experimental Physiology Including General Physiology
A Laboratory Manual of Experimental Physiology Including General Physiology
Lois Mcphedran Fraser
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Even the elimination of reflex vagus effects may not suffice to demonstrate the pressor or depressor influence because of the pre- dominance of the respiratory effects. It may be necessary to eliminate the latter, which can be done by injecting through the femoral vein a saturated solution of curare in physiological saline. * Under the influence of curare the respirations cease, and to keep the animal alive it is necessary to connect the respiratory pump to the tracheal cannula, with the anaest...hetic bottle inserted in the tubing. *The curare solution should be prepared several days previously and should be tested on a frog before using in the above experiment. The curare at present on the market is very unreliable. VASCULAR AND RESPIRATORY ORGANS. 201 (Etherisation must be maintained, otherwise the animal might suffer pain. Why?) While maintaining the artificial respiration the sciatic and vagus nerves are stimulated as before. What conclusions can be drawn from the results? The effect of asphyxia on the arterial blood pressure is then studied, the asphyxia being induced by suspending the artificial respiration.
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