A Physical Interpretation of Shock Exhaustion And Restoration An Extension of

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A Physical Interpretation of Shock Exhaustion And Restoration An Extension of
George Washington Crile
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The clinician sees even more striking evidence of this increased activation of the brain in the behaviour of his patient under light ether. In exophthalmic goiter cases, the organism is especially sensitised, and in these the first stage of ether anesthesia gives striking evidence of increased activation. As stated above, we may conceive that this striking activation of the organism and the consequent increase in metabolism in the early stage of ether anesthesia is due to an increased permeabil...ity of the membranes of the brain-cells. We may suppose that ether causes a great increase in the metabolism of the cells, a great increase in the formation of electric energy, which escapes readily through the lowered resistance of the cell boundaries and of the synapses, and in consequence we may presume that heavy charges of electricity are freed from the cells, and run over the open nerve paths leading to the various muscles and glands. There being no adaptive lead over any facilitated action pattern, the muscular and the glandular response is as free from purposeful action as in a convulsion and, indeed, in many respects, the first stage of anesthesia resembles a general convulsion.

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