A Text-Book of Medical Chemistry And Toxicology

Cover A Text-Book of Medical Chemistry And Toxicology
A Text-Book of Medical Chemistry And Toxicology
James W. Holland, A.M, M.D
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Uric acid.
Digitized by Google 492 CYCLIC COMPOUNDS Uracil, C4H4N2O2, has been found in the nucleoproteins, and so has thymin, QHjNjOj . CHj, which is methyluracil. Cytosin, C4H5N8O, is a constant cleavage product of the nucleic acids. It is so intimately related to the purin group that it is supposed to be the mother-substance.
Uric acid in the urine is derived from two sources — the inUrnal and the external^ or endogenous and exogenous. The endogenous uric acid comes from the nucleins of the
...body cells and their decomposition products, the purin bases. The quantity for each individual is fairly constant and uninfluenced by food. The exogenous uric acid arises from the nucleins and purin bases con- tained in the food. It is, therefore, an addition to the normal quan- tity and is dependent entirely on the amount of combined and free oxypurins and aminopurins in the food. These are abundant in sweetbreads (thymus gland), liver, kidney, meat soups, peas, beans, asparagus, heavy wines, meats, and fish.

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