A Text book of Pathological Anatomy And Pathogenesis volume 1
A Text book of Pathological Anatomy And Pathogenesis volume 1
Ernst Ziegler
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Vol. 73). In connective tissue it is less easy to exclude the possibility of cell-infiltration from neighbouring parts. VIRCHOW has thus shown that sarcoma-cells may arise by proliferous multiplication from connective-tissue cells of perfectly normal aspect. This is the process in a large number of cases ; but it may vary to this extent that the development begins in tissue which is already morbidly altered. Thus new-formed cartilage may pass into sarcoma by over-intense proliferous growth of t...he cartilage- cells, and disappearance of the matrix-substance. It is of great interest to note that cells, which form part of what we might call congenital heteroplastic foci, may often serve as the starting point of a sarcoma. Congenital warts and pigment- spots are specially remarkable for this. The transformation into sarcomatous tissue is effected by the growth and multiplication of the nests of cells that are always found in such spots. Summing up what we know of the development of sarcoma we may say that sarcomatous tissue may arise either from connective tissues which up to then seem normal, or from tissues that are to be regarded as already morbid.
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