Addresses & Papers, Dedication Ceremonies And Medical Conference, Peking Union Medical College : September 15-22, 1921, Peking, China

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At least one would have to prove that the differentiated cells which normally made the syncytial masses of angioblasts could be made to develop granulocytes. The argument for the mesenchyme cell as the stem cell for the three distinct strains of cells which contribute to the blood, is that three such groups can be isolated embryologically and they correspond to a functional classification. At least one may say that no common differentiated stem cell has been adequately demonstrated.
LYMPHOCYTES
... In these studies of the development of blood in a living form, the account of the origin of the lymphocytes is very incomplete. The lymphocytes make a group of cells ranging in the mammal from the size of a red cell up to cells twice the size. Likewise in the chick the lymphocytes are the smallest cell. When the cell first appears, all of them are of the small size. The cell has a characteristic nucleus and its cytoplasm contains a few azurophilic granules, discovered by Michaelis and Wolff (30).

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