An Introduction to the Study of Infection And Immunity Including Chapters On Se
An Introduction to the Study of Infection And Immunity Including Chapters On Se
Charles E Charles Edmund Simon
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In the case of the rabbit, on the other hand, such an effect can be produced not only by the cells of the nervous system, but also by the liver and the spleen. If, moreover, a guinea-pig is injected with tetanus toxin the fatal dose is the same, no matter whether the poison is injected intracerebrally, intravenously, or subcutaneously. In the rabbit the result is dif- ferent. Intracerebral injection of tiny doses readily leads to fatal tetanus, while much larger amounts can be administered sub-... cutaneously without causing a fatal result, particularly if the larger nerve trunks in the district in which the injection is made are previously cut. As abundant antitoxin formation then takes place notwithstanding the fact that the access of the toxin to the brain has been excluded so far as possible, the inference, of course, is perfectly warrantable that the antitoxin in question is largely produced by cells which are not susceptible to the toxic action of the poison. The same point is also well illustrated in the case of the alligator.
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