An Introduction to the Study of the Endocrine Glands And Internal Secretions; Lane Medical Lectures, 1913

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It has, therefore, been concluded that under the influence of these nerves the tissues produce either at the junction of nerve and mus- cle (myo-neural junction of Elliott) or throughout the cell-protoplasm a material ("receptive or excitable substance" of Langley) which reacts with adrenine, and not only with it but also with other drugs, such as certain alkaloids which have a pronounced physiological action. And further, that this receptive substance increases either in amount or sensi- tivit...y after the action of the nerves is withdrawn by their severance.
A very minute dose of the active substance may, as Moore and Purinton showed, produce the reverse action upon the bloodvessels, viz., dilatation instead of contraction. Abolition of the effect of adrenine in producing contraction of plain muscle (and the same applies to the effects of sympathetic excitation) can, as Dale has shown, be obtained by exhibition of ergotoxin — an amine base ob- tained from ergot and also obtainable from the products of breaking down of histodlne.


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