Anatomy of An Epidemic (2010)

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—NATHAN KLINEDIRECTOR OF RESEARCH AT ROCKLAND STATEHOSPITAL IN NEW YORK (1974)1 The “magic bullet” model of medicine that had led to the discovery of the sulfa drugs and antibiotics was very simple in kind. First, identify the cause or nature of the disorder. Second, develop a treatment to counteract it. Antibiotics killed known bacterial invaders. Eli Lilly’s insulin therapy was a variation on the same theme. The company developed this treatment after researchers came to understand that diabete...s was due to an insulin deficiency. In each instance, knowledge of the disease came first—that was the magic formula for progress. However, if we look at how the first generation of psychiatric drugs was discovered, and look too at how they came to be called antipsychotics, anti-anxiety agents, and antidepressants—words that indicate they were antidotes to specific disorders—we see a very different process at work. The psychopharmacology revolution was born from one part science and two parts wishful thinking.

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