Applied Physiology a Handbook for Students of Medicine

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Some (e. G. , Wolff) go so far as to regard the lymphoid cell as the original parent from which all the cells of the blood are derived, according to the following scheme : Lymphoid cell.
I ! I Large lymphocyte. Erythrocytes. Myelocytes Small lymphocyte. (a) Basophil.
(6) Neutrophil.
Polynuclear leucocytes (a) With basophil granulation. (/3) With neutrophil granulation.
In process of development, according to this view, a gradual differentiation of function takes place on the part of the blood-f
...orming organs, in consequence of which the lymphoid cells of the marrow confine them- selves to the production of granular cells, whilst those of the adenoid tissue become exclusively concerned in the production of non- granular cells (lymphocytes). The specialization, however, is never so complete but BLOOD AND H^MOPOIETIC ORGANS 85 that, when a demand for a greater number of cells of one type occurs, the lymphoid cells in any blood-forming organ are able to produce that type.
The place of origin of the large mononuclears and of the transitional cells derived from them is uncertain, but it is probably in the bone marrow, though in part also they may come from the lymph glands and the spleen.


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