Applied Physiology; a Handbook for Students of Medicine

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It is probable that the marrow is the sole seat of origin of the granular cells, and that the adenoid tissue is the chief breeding-ground of lymphocytes. Whether or not the latter are also produced in the marrow, or, to put it otherwise, whether or not the marrow, like other tissues, also contains some adenoid tissue, is still disputed. In lymphatic leukaemia the red marrow becomes virtually converted into a mass of adenoid tissue, with the natural result that the granular cells disappear almos...t entirely from the blood. Whether such a replacement of the normal marrow is to be regarded as an invasion by lymphocytes or a mere hypertrophy of already existing adenoid tissue depends upon the view one takes as to whether or not lymphocytes are a natural product of the marrow.
6—2 84 APPLIED PHYSIOLOGY The mother cells of the granular leucocytes in the marrow are large clear cells with a single nucleus ('lymphoid' cells). By the deposition of granules in their protoplasm these become converted into granular myelocytes in which the nucleus is still single, and these are the cells so largely present in the blood in myelogenous leukaemia.


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