Behavior/stress Interactions in Diabetes Mellitus

Cover Behavior/stress Interactions in Diabetes Mellitus
Behavior/stress Interactions in Diabetes Mellitus
Bellush, Linda L.
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The present results demonstrated better retention for passive avoidance in diabetic rats and a number of hormonal and neurochemical differences which may help to account for 170 the behavioral differences. It would be of interest in future experiments to extend the behavioral findings to additional learning situations. In particular, it would be instructive to determine if appetitive learning, which presumably is not as stressful as passive avoidance, would be different in diabetic and nondiabe
...tic rats.
It would also be interesting to determine if extended exposure to stress, as in the 72 hours of cold exposure here, has an influence on behavioral variables, since the present results indicated more rapid response of norepinephrine excretion to cold in diabetic rats and an apparent depletion in renal dopamine production after 72 hours. The cold environment also led to significantly higher concentrations of norepnephrine in frontal cortex and brainstem of diabetics. In addition, diabetics had reduced DOPAC to DA ratios in frontal cortex and brainstem and reduced DOPAC concentration in brainstem.


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