Bodily Changes in Pain, Hunger, Fear, And Rage; An Account of Recent Researches Into the Function of Emotional Excitement
Bodily Changes in Pain, Hunger, Fear, And Rage; An Account of Recent Researches Into the Function of Emotional Excitement
Walter B Walter Bradford Cannon
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And its property of turning to a jelly soon after escap- ing from its natural channels assures a closure of the opening through which the escape occurred, and thus protection of the body from further bleeding. The slight evidence that adrenin hastens the clot- ting process has already been hinted at When we 135 136 BODILY CHANGES found that adrenin is set free in pain and intense emotion^ it seemed possible that there might exist in the body an arrangement for making doubly- sure the assurance ...against loss of blood, a proc- ess that might nicely play its role precisely when the greatest need for it would be likely to arise. It was in 1903, while tracing in dogs the rise and fall of sugar in the blood after administering adrenin, that Vosburgh and Richards ^ first noted that simultaneously with the increase of blood sugar there occurred more rapid coagulation. In some cases the diminution was as much as four- fifths the coagulation time of the control. Since this result was obtained by painting "adrenalin" on the pancreas, as well as by injecting it into the abdominal cavity, they concluded that "the phe- nomenon appears to be due to the application of adrenalin to the pancreas." Six years later, dur- ing a study of the effect of adrenalin on internal hemorrhage, Wiggers ^ examined incidentally the evidence presented by Vosburgh and Richards, and after many tests on five dogs found "never the slightest indication that adrenalin, either when injected or added to the blood, appreciably hast- ened the coagulation process." In 1911 von den Velden* reported that adrenin (about 0.007 mil- ligram per kilo of body weight) decreased the coagulation time in man about one-half — an effect appearing 11 minutes after administration by FASTER COAGULATION BY ADRENIN 137 mouthy and 85 minutes after subcutaneous injec- tion.
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