Bovine Tuberculosis And Its Control

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a Paris, 1898.
IMMUNIZATION OF CATTLE 77 Koch- came to the conclusion that it was necessary, in the treatment of tuberculosis, to produce not only an immunity to toxins, but also a bacterial immunity, and felt that he had seen evidence of an immunity of a degree sufficient to be of much value. He had observed, in acute miliary tuberculosis, when the bacteria are distributed throughout the entire body, a stage during which the organisms, formerly so numerous, disappear to such an extent that the
...y can be found only with difficulty. It appeared, therefore, that even in these cases there was a sort of bacterial immunity.
Antitoxins found in the blood of animals that have been treated with various toxins or tuberculins have been used to a large extent experimentally for the purpose of immunizing animals against, and treating animals infected with, tuberculo- sis. Maragliano^ was one of the first workers in this field. He obtained what he believed to be a curative serum by injecting toxins produced by or extracted from tubercle bacteria into experimental animals — i.


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