Catalytic Action
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Bayliss, Proc. Roy. Soc. London (B) 84, 81 (1911).
6 T. B. Osborne and G. F. Campbell, Jour. Amer. Chem. Soc. 18, 536 (1896) ; H. C. Sherman and co-workers, series of papers in Jour. Amer. Ghem. Soc. 1914-1921.
ENZYME ACTIONS 121 dium is naturally the first factor to be thought of in this con- nection, because of the optimum conditions which have been found to exist for all enzyme actions. Similarly there may be optimum conditions for the substrate, as with the protein ions which Northrop showe...d were essential for optimum pepsin ac- tion. Also, there may be optimum conditions for the decomposi- tion of the intermediate addition compound which may be differ- ent from the optimum conditions for its formation.
The actions of foreign substances, foreign in the sense that they are not involved in the simplest formulations of the reac- tions, may exert considerable influence. Thus, they may com- bine with the enzyme, a reaction similar to equation (c) of the general formulation, in a reversible or irreversible way, and re- move it from the sphere of action; they may combine with the products of the reaction, and by removing them favor the en- zymic decomposition; they may combine with the substrate, or cause a change in it which would interfere with the reaction; etc.
What to read after Catalytic Action?
You can find similar books in the "Read Also" column, or choose other free books by Kaufman George Falk to read onlineMoreLess
To quickly assess the difficulty of the text, read a short excerpt:
Bayliss, Proc. Roy. Soc. London (B) 84, 81 (1911).
6 T. B. Osborne and G. F. Campbell, Jour. Amer. Chem. Soc. 18, 536 (1896) ; H. C. Sherman and co-workers, series of papers in Jour. Amer. Ghem. Soc. 1914-1921.
ENZYME ACTIONS 121 dium is naturally the first factor to be thought of in this con- nection, because of the optimum conditions which have been found to exist for all enzyme actions. Similarly there may be optimum conditions for the substrate, as with the protein ions which Northrop showe...d were essential for optimum pepsin ac- tion. Also, there may be optimum conditions for the decomposi- tion of the intermediate addition compound which may be differ- ent from the optimum conditions for its formation.
The actions of foreign substances, foreign in the sense that they are not involved in the simplest formulations of the reac- tions, may exert considerable influence. Thus, they may com- bine with the enzyme, a reaction similar to equation (c) of the general formulation, in a reversible or irreversible way, and re- move it from the sphere of action; they may combine with the products of the reaction, and by removing them favor the en- zymic decomposition; they may combine with the substrate, or cause a change in it which would interfere with the reaction; etc.
What to read after Catalytic Action?
You can find similar books in the "Read Also" column, or choose other free books by Kaufman George Falk to read onlineMoreLess
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