Chemical Basis of Pharmacology An Introduction to Pharmacodynamics Based On the
Chemical Basis of Pharmacology An Introduction to Pharmacodynamics Based On the
Francis V. R.
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NH;H 1. CH 2 < ! +HC1 X CH 2 . CH 3 . JNH 2 2.
One method used in the synthetic formation of pyridine deriva- tives is due to Hantzch, and consists in the condensation of /3-keto compounds (such as acetoacetic ester) with aldehydes and ammonia.
An example of this condensation is seen in the following forma- tion of dihydro-collidine-dicarboxylic ester by the interaction of acetaldehyde, ammonia, and acetoacetic ester CH 3 CH A- H 2 C 2 H 6 OOC. CiH HiC. COOCoH ;.
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