Disease And Its Causes

Cover Disease And Its Causes
Disease And Its Causes
W T William Thomas Councilman
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The amount of amboceptor may increase in the course of infection and its for- mation stimulated, the amount of complement DISEASE AND ITS CAUSES 153 remains unchanged. The action of the ambo- ceptor is specific, that is, directed against a single species of bacterium only; the destructive power of the blood may be very great against a single bacterium species and have no effect on others. There seem naturally to be many different amboceptors in the blood, and the number may be very greatly incr...eased. It has been shown as a result of the work of many investigators that the shield has two faces, there is destruction both by cells and fluids and there is interaction by both. The amboceptors so necessary for the destructive action of the serum are produced by the body cells, particularly the leucocytes. The serum assists in pagocytosis by the action on bacteria of substances called opsonins which are contained in it, and the formation of which can be very greatly stimulated. Again, not all inclusion of bacteria within leucocytes is indica- tive of phagocytosis; in many cases the bacteria seem to find the best conditions for existence within the leucocytes, and these and not the bacteria are destroyed.

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