Essentials of Bacteriology; Being a Concise And Systematic Introduction to the Study of Bacteria And Allied Microörganisms
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Toxins of Diphtheria. — Roux and Yersin, in 1888, discov- ered the toxin and showed that the injection of the filtered culture bouillon (that is, freed of all diphtheria bacilli) gave rise to the same palsies as when the bacUli themselves were introduced.
The toxins may be separated from three-weeks-old bouillon cultures by filtration. They are not albumins and are very complex. Ehrhch claims three forms: one he calls toxone; the other, toxin; the toxone produces paralytic sjmiptoms and appears... to be less affected by antitoxin; the third, toxoid, combines with antitoxin. The toxins are highly poisonous — o.ooi c.c. may be sufl&cient to kill a guinea-pig in less than twenty-four hours. The substance is unstable, losing its toxic power gradually. Heating at 58° C. for two hours is destruc- tive, but drying renders it more stable. Direct sunlight destroys its power in a few hours. Boiling in five minutes.
If kept cold and in the dark, it may remain active two years.
Alcohol and calcium chlorid precipitate the toxic element.
What to read after Essentials of Bacteriology; Being a Concise And Systematic Introduction to the Study of Bacteria And Allied Microörganisms?
You can find similar books in the "Read Also" column, or choose other free books by Ball, M. V. (Michael Valentine), B. 1868 to read onlineMoreLess
To quickly assess the difficulty of the text, read a short excerpt:
Toxins of Diphtheria. — Roux and Yersin, in 1888, discov- ered the toxin and showed that the injection of the filtered culture bouillon (that is, freed of all diphtheria bacilli) gave rise to the same palsies as when the bacUli themselves were introduced.
The toxins may be separated from three-weeks-old bouillon cultures by filtration. They are not albumins and are very complex. Ehrhch claims three forms: one he calls toxone; the other, toxin; the toxone produces paralytic sjmiptoms and appears... to be less affected by antitoxin; the third, toxoid, combines with antitoxin. The toxins are highly poisonous — o.ooi c.c. may be sufl&cient to kill a guinea-pig in less than twenty-four hours. The substance is unstable, losing its toxic power gradually. Heating at 58° C. for two hours is destruc- tive, but drying renders it more stable. Direct sunlight destroys its power in a few hours. Boiling in five minutes.
If kept cold and in the dark, it may remain active two years.
Alcohol and calcium chlorid precipitate the toxic element.
What to read after Essentials of Bacteriology; Being a Concise And Systematic Introduction to the Study of Bacteria And Allied Microörganisms?
You can find similar books in the "Read Also" column, or choose other free books by Ball, M. V. (Michael Valentine), B. 1868 to read onlineMoreLess
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