Experimental Pharmacology
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In our eReader you can find the full English version of the book. Read Experimental Pharmacology Online - link to read the book on full screen. Our eReader also allows you to upload and read Pdf, Txt, ePub and fb2 books. In the Mini eReder on the page below you can quickly view all pages of the book - Read Book Experimental Pharmacology
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e., the action of one drug is not equal and opposite to the action of the other. Small doses of atropin will counteract the effects of large doses of pilocarpin, but pilocarpin is not antagonistic to large doses of atropin. In this as in m.ost cases the paralyzing drug is much stronger than the stimulating drug.
The antagonism may be explained in this case by assuming that these drugs act on the same place: the myoneural junctions, one stimulating, the other depressing. When the ending is paral...yzed by atropin, of course, no further acticm can be expected, since paralysis requires a i)eriod of recuperation before the ending is again rcsjxmsive to any stimulus.
On striix'd muscle, curara i)aralyzes the nerve-endings; eserin here is antagonistic, but the degree of the antagonism is again limited. The effect of curara soon wears off, but eserin facilitates the r(!Cuperation and actually stimulates the endings.
164 ANTAGONISM In the case of veratrin, which acts directly on muscle and stimu- lates it, potassium chloride and fatigue products are antagonistic, and again the paralyzing drugs are stronger than the stimulating.
What to read after Experimental Pharmacology?
You can find similar books in the "Read Also" column, or choose other free books by Mcguigan, Hugh, 1874- to read onlineMoreLess
To quickly assess the difficulty of the text, read a short excerpt:
e., the action of one drug is not equal and opposite to the action of the other. Small doses of atropin will counteract the effects of large doses of pilocarpin, but pilocarpin is not antagonistic to large doses of atropin. In this as in m.ost cases the paralyzing drug is much stronger than the stimulating drug.
The antagonism may be explained in this case by assuming that these drugs act on the same place: the myoneural junctions, one stimulating, the other depressing. When the ending is paral...yzed by atropin, of course, no further acticm can be expected, since paralysis requires a i)eriod of recuperation before the ending is again rcsjxmsive to any stimulus.
On striix'd muscle, curara i)aralyzes the nerve-endings; eserin here is antagonistic, but the degree of the antagonism is again limited. The effect of curara soon wears off, but eserin facilitates the r(!Cuperation and actually stimulates the endings.
164 ANTAGONISM In the case of veratrin, which acts directly on muscle and stimu- lates it, potassium chloride and fatigue products are antagonistic, and again the paralyzing drugs are stronger than the stimulating.
What to read after Experimental Pharmacology?
You can find similar books in the "Read Also" column, or choose other free books by Mcguigan, Hugh, 1874- to read onlineMoreLess
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