Experimental Pharmacology, a Laboratory Guide for the Study of the Physiological Action of Drugs
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Just as voluntary activity ceases stimulate the skin of the poisoned leg. The unpoisoned gastrocnemius will contract. Rapidly expose and stimulate the poisoned sciatic. The poisoned gastroc- nemius will not contract, while the unpoisoned one will, owing to reflex stimulation through the cord. 5. Curare on the mammal. Morphinize and chloroform a dog. Take blood-pressure. Introduce a tracheal canula and take the respiratory record by the intra-tracheal method. Arrange the apparatus for artificial... respiration when needed. Inject into a vein 5 c.c. of i percent curare. All movements of voluntary muscles will quickly cease including respiratory movements. The heart rate and the blood-pressure remain good, and if artificial respiration is applied the circulation can be maintained for several hours, or until the drug is eliminated and recovery occurs. 42 EXPERIMENTAL PHARMACOLOGY. PILOCARPINE. Experiments Showing the Action of Pilocarpine. 1. On the frog 2. On the mammal On the ventricular muscle .
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