General Physiology of Muscles And Nerves

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But the process, if intelligible, is yet not explained. An attempt at explanation must be based on, and have regard to, all the established facts.
3. It is natural to think of the electric characters of nerves and muscles, and to seek the explanation in i,hese. In nerves electric tensions prevail which dur- ing the activity of the nerve undergo a sudden decrease, a so-called negative variation. Such sudden variations of electric currents are, we know, able to excite the 248 PHYSIOLOGY OF MUSCLE
...S AI^D NERVES muscle. We may, therefore, conceive the process some- what as follows. The excitement in the nerve, however caused, propagates itself along the nerve-fibre until it reaches the end of the latter. Connected with it is an electric process, by which a sudden electric variation is caused in the terminal apparatus of the nerve- fibre, and this excites the nerve-substance, just as a shock acting externally immediately on the muscle would excite it.
Following du Bois Eeymond, the above conception may be called the discharge-hypothesis (Entladwags- hypothese).


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