Histology of the Blood

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From the first Ehrlich has insisted, =thatdifferent kinds of cells possess different granules=, distinguished notonly by their tinctorial properties, but also by their various reactionsto solvents.
It is in this connection indeed, that Altmann's method, consisting of acomplicated hardening process, and the use of a single, always similarstain, constitutes a retrograde step, in as much as it tends to obscurethe principle of the specificity of each kind of granulation.
A further disadvantage of A
...ltmann's hardening method lies in thecircumstance, that the cell proteids are precipitated by it in aspherical form, and stain in the subsequent treatment. Hence it isextremely difficult to distinguish what is preformed, and what isartefact. Since A. Fischer's publication, where the formation ofgranule-like precipitates under the influence of various reagents isexperimentally demonstrated, grave doubts as to the reality of Altmann'sforms have been raised from various quarters. Ehrlich's dry process, onthe contrary, is entirely free from error.

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