Immunity And Specific Therapy

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There is also a little evidence for the forma- tion of a true antitoxin against the actual and efficient toxin of the streptococcus, whatever this may be. This is the fact that in some cases, though unfortunately not in all, the injection of anti- streptococcic serum is followed by a marked immediate benefit in cases of septicaemia, etc. The temperature may fall, the delirium and headache pass off, and the pulse improve in a striking manner within an hour or two of the injection. Now Wright has... pointed out that but little is known of the mode of action of the serum, and that it may contain a toxic ingredient and really be a vaccine in disguise. If this is the case we should not expect it to produce good effects so early as actually happens in favourable cases, in which its action resembles that of diphtheria antitoxin, and certainly suggests that some poison is neutralized. Probably, therefore, acquired immunity to streptococci is partly antitoxic or anti-endotoxic.
Bacterial immunity is probably mixed, partly bactericidal or bacteriolytic and partly phagocytic.


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