Life of Elie Metchnikoff, 1845-1916

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All these experiments proved that the extra- cellular destruction of the cholera vibrio was accom- plished by the digestive juices which had passed from the phagocytes into the humors and not at all through a special property of those humors. Once again the phagocyte theory rose triumphant from the test.
After having finally proved that it is by means of its phagocytes that the organism fights microbes, Metchnikofi wished to find out whether it was by the same process that it struggled with the
...ir poisons, or toxins. This problem, far more difficult to solve, took him many years' study. Whilst every phase of the phagocytes' struggle agaiast microbes can be LIFE OF ELIB METCHNIKOFF 161 followed with the eyes, it is impossible to do so where poisons are concerned, since they are invisible ; it is necessary to proceed by a different road.
Faithful to his method of taking as a starting-point the simplest expression of the phenonxenon to be studied, Metchnikofi began by lower beings. Uni- cellular organisms, such as myxomycetes, amoebae, and infusoria, sometimes manifest a natural immunity to certain poisons.


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