Local Immunity

Cover Local Immunity
Local Immunity
Charles Robert Lard Arths
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0, 000, 001 c. C. Were used.
After this experiment, another was made in order to determine whether three small doses of pneumococcus vaccine Injected intratracheally would confer an c^dequate immunity. The total dosage of vaccine injected was equivalent to approxi- 28 mately one-tenth of the total dosage employed in the first experiment.
One of the monkeys whose feet was infected de- veloped pneumonia after inoculation with living pneuinococci, The other two remained healthy in spite of the ino
...culation. The control developed pneumonia. The failure to immunize one of the monkeys has been explained by the authors by the existing Infected feet, lov/ering its resistance. A similar result has b^en observed in man. The successful immuniza- tion of monkeys by three small intratracheal doses of vac- cine indicates that iramvmlty is more readily induced by the Intratracheal route than by the subcutaneous route. "The im- munity induced by the intratracheal injection of pnevimococci vaccine is probably, to a great extent, a cellular immunity.

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