Manual of Bacteriology

Cover Manual of Bacteriology
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The path of infection may alter the result, serious effects often following a direct entrance into the blood stream. Staphy- lococci injected subcutaneously in a rabbit may produce only a local abscess, whilst on intravenous injection multiple abscesses in certain organs may result and death may follow. Local inflammatory reaction with subsequent destruction of the organisms may be restricted to the site of infection or may occur also in the lymphatic glands in relation. The latter therefore ac
...t as a second barrier of defence, or as a filtering mechanism which aids in protecting against blood infection. This is well illustrated in the case of " poisoned wounds. " In some other cases, however, the organisms are very rapidly destroyed in the blood stream, and Klemperer has found that in the dog, subcutaneous 142 RELATIONS OF BACTERIA TO DISEASE.
injection of the pneumococcus produces death more readily than intravenous injection.
2. The Subject of Infection. Amongst healthy individ- uals susceptibility and, in inverse ratio, resistance to a particular microbe may vary according to (a) species, (ft) race and individual peculiarities, (c) age.


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