Manual of Practical Physiology, Designed for the Physiological Laboratory Course in the Curriculum of the American Association of Medical Colleges

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Therefore, the only universally applicable means to regulate the onset and rate of chemical reaction are the enzymes or catalyzers.
To designate the organic ferments as catalyzers is, however, not a justified nomenclature if the term is used to mean simply an accelerator. For the organic enzymes are more than accelera- tors — they actually initiate the process that is peculiar to their specific work. Solutions of sugar, albumins and peptones do not undergo splitting up or oxidation spontaneousl
...y and have been kept in an undecomposed state for years; but on contact with the proper enzyme they underwent hydrolytic cleavage at once.
Recent work by Abderhalden and Gigon (Zeitschr. f.
physiol. Chemie, 53, 251, 1907) also indicates that ferments actually enter into a chemical union with the substrate but this union is dissolved again and this is the reason why they were believed to act catalytically, and that they could transform an enormous quantity of the substrate compared to their own weight.


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