Medico-Chirurgical Transactions 65

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But there are still traces of the original plan of glandular structure underlying that radically new cancerous process.
The formation of rows of epithelial cells in the interstices of the connective tissue in many places follows concentric lines round the original gland tubules. The epithelial new formation breaks out in ever- widening circles in the tissue surrounding the tubule, so that there results an appearance as if the tubule had been greatly dilated, and as if the dilated cavity had com
...e to be occupied with linear columns of epithelium. That extension of the area of the original tubule is not a mechanical encroachment upon the surrounding connective tissue, but it is a trans- forming encroachment, whereby the cells of the connective tissue become epithelial cells, and are left lying in suc- cessive concentric rows within a wide space continuous with the original lumen of the gland. The first step in that remarkable process of cancerous invasion appears to be illustrated in some of the tubules of tumour No.

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