Micro-Organisms And Disease: An Introduction Into the Study of Specific ...

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Micro-Organisms And Disease: An Introduction Into the Study of Specific ...
Edward Emanuel Klein
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Koch 1 described various kinds of micrococci inti- mately connected with certain destructive (pyaemic) processes in mice and rabbits, (a) Micrococcus of progressive necrosis in mice. Injecting into the ear of mice — white mice, or better, field mice — putrid fluids, he observed a necrosis of the tissues of the ear (skin, cartilage) starting from the point of inocula- tion and gradually spreading on to the surrounding parts and killing the animal in about three days. As far as the necrosis reach...es, the tissue is crowded with micrococci, chiefly in the form of chains and zoogloea. The individual cells are spherical, of about 0*0005 mm. in diameter. I may mention that I have found a somewhat different micrococcus virulently active on mice. I have inoculated a number of white mice subcutane- ously in the tail with a small micrococcus cultivated through several generations, and apparently derived from an artificial cultivation in pork broth, but due to accidental contamination.
These micrococci, after having been cultivated in pork broth through several generations, were used in infinitesimal doses for the inoculation of the above mice.


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