North Carolina Awards [serial] 1974

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Hanes professor and chairman of the department of medicine at Duke University, he is best known for his research on biochemical control mechanisms and his applications of biochemistry to the treatment of disease.
He is an authority on uric acid metabolism and published a definitive paper on gout in "The Metabolic Basis of Inherited Disease", which he coedited. Recently he was chosen to coedit the fifteenth edition of the Textbook of Medicine. He was one of the first investigators to demonstrate
..., in the 1950s, cooperative feedback inhibition of allosteric control of enzyme activity, a study which has had a major impact on subsequent investigations of the mechanisms through which biochemical control is effected. An outstanding clinician, as well as a scholar of national reputation, Dr.
Wyngaarden provided much of the impetus to develop both Duke's research train- ing program and the school's present curriculum, with its emphasis on the basic sciences. In effect he serves as a model for, as well as a participant in.


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