On the Escape of the Heart From Vagus Inhibition

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The conditions of their appearance afford very strong evidence that a weak heart is more easily inhibited than a strong one.
To recapitulate the arguments adduced in the above discussion : — 1. In the vigorous heart of the cat no strength of stimulation can cause great slowing, while in a heart which has been appreciably weakened the slowing produced is always decided, and frequently amounts to stand-still. 2. When the heart of the same animal becomes gradually or suddenly weaker in the course
...of an experiment a decided increase in inhibitory efficiency is noticed ; conversely, when the heart becomes stronger during the same experiment, strengths of stimulation which at first were able to cause stand-^till are no longer able to do so. 3. Other things being equal, the duration of stand-still or of a certain amount of inhibition is greater in weak hearts than in strong ones. 4. The heart of a dog or a cat, weakened by repeated inhibitions, very frequently toward the end of the experiment shows itself unable to escape effectively to a regular rate and force of beat.

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