On the Mechanism of the Physiological Action of the Cathartics

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m/8 sodium citrate applied locally.
Fluid secreted during 1st 10 minutes 0.4 c.c.
Fluid secreted during 2d 10 minutes 0.2 ce.
37 2. Babbit. Loop 25 cm. long.
Loop contained in beginning 2.0 c.c.
Fluid secreted during 1st 10 minutes 0.8 c.c.
Fluid secreted during 2d 10 minutes 0.4 c e.
2 c.c. m/8 CaClj applied locally to serous surface.
Fluid secreted during 1st 10 minutes following appli- cation 0.0 c.c.
Fluid secreted during 2d 10 minutes following appli- cation 0.0 C.C.
4 c.c. m/8 sodium citr
...ate applied locally.
Fluid secreted during 1st 10 minutes 0.6 c.c.
3. Babbit. Loop 22 cm. long.
Loop contained in beginning 2.4 c.c.
Fluid secreted during 1st 10 minutes 1.2 c.c.
Fluid secreted during 2d 10 minutes 1.15 c.c.
3 c.c. m/8 MgClj applied locally to serous surface.
Fluid secreted during 1st 10 minutes following appli- cation 0.0 a.e.
Fluid secreted during 2d 10 minutes following appli- cation 0.0 c.c.
Fluid secreted during 3d 10 minutes following appli- cation 0.2 c.c.
Although in these experiments the quantity of fluid secreted is small, there is a definite cessation of this excre- tion following the application of calcium or magnesium chloride.


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