On the Rhythm of the Heart of the Frog, And On the Nature of the Action of the Vagus Nerve. the Croonian Lecture

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Very soon after this curve was taken the muscarin caused the action of the motor ganglia to cease altogether, and then it was found that stimulation of the vagus was unable' to make either ventricle or auricle beat.
Tills shows that the vagus is not a motor nerve to the muscle, for if it were so it must have caused contractions of the ventricle, seeing how powerfully it had been able to aflPect the ventricle a A-ery short time before.
Again, cases occur where the cuives show that muscarin appli
...ed to the auricular side only had very greatly reduced the size of the auricular beats, somewhat slowed the rhythm, and by its weakening action on the strength of the impulses caused the ventricle (which had previously been beating synchronously with the auricles) to remain quiescent. Stimulation of the nerve produced only a slight quickening of the auricular beats, and after the end of the stimulation a series of ventricular beats similar to what has already been described when the ventricles were reduced to standstill either by clamping or heating the auricles and sinus.

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