Pathology of the Nervous System

Cover Pathology of the Nervous System
Pathology of the Nervous System
E Farquhar Edward Farquhar Buzzard
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It is thus clear that this hypertrophy is a morbid change with a MYOPATHY 77 p^^i^p^- 4, '^^: ^- - ' Fig. I6. Muscle in the pseudo-hypertrophic form of myopathy.
y% AMYOTONIA CONGENITA great tendency to further degeneration. The muscle fibres are also seen to undergo a retrogressive change into fibrous tissue, especially in the neighbourhood of the tendinous attachments. It is doubtful whether the encroachment of tendinous fibrous tissue which undoubtedly takes place at both ends of an affected
... muscle is due to this retrograde metaplasia of muscle fibres or to their atrophy and a simultaneous increase of the interstitial connective tissue. Probably both these factors are at work. Eventually the picture presented is that of a few scattered fibres, some larger than normal, others small, atrophic, and irregularly shrunken, separated by a large amount of fibrous and fatty tissue.
Morbid changes have been described in the motor nerve endings, but the muscle spindles have been found intact even in advanced stages of the disease.


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