Physiological Chemistry; a Text-Book And Manual for Students

Cover Physiological Chemistry; a Text-Book And Manual for Students
Physiological Chemistry; a Text-Book And Manual for Students
Mathews, Albert Prescott, 1871-
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Injection of thyroid extract causes a stimulation of the protein catAbo- lism of the body. It is interesting that it also causes an increase in the creatine excretion (acetoacetic acid?). Just how this result is pro- duced it is impossible to say. It might be that the thyroid extract caused directly or indirectly the discharge of creatine from the muscles so that the excretion is increased. It may be that the creatine acts as a brake on the protein catabolism and its removal results in an abnor
...mal catabolism of proteins.
Origin of creatinine. The foregoing facts show that the creatine and the creatinine of the urine have the same origin, and that creatinine is derived from the creatine of the tissues of the body. There is in the body of an average adult something more than 120 grams of creatine.
That this creatine gives rise to the creatinine of the urine is indi- cated not only by the facts cited, but also by the following observa- tions of Meyers and Fine: Creatine— Creatinine— Ratio- Ratio- muscle per cent.


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