Practical Diagnosis; the Use of Symptoms And Physical Signs in the Diagnosis of Disease

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The white blood corpuscles are normal in number, or decreased, with a rela- tive increase of lymphocytes and possibly a few myelocytes, although the great diminution in the red cells renders the proportion of white to red greater than normal. Cases of pernicious anemia in which there are no regenerative changes in the bone-marrow are known as aplastic anemia. This type is rapidly fatal, the chief differences in the blood picture from that described being a low color index and the absence of meg...aloblasts.
Another form of anemia, which at one time was considered secondary but now classed as primary, is called chlorosis. In this state the corpuscular diminution is so slight that it maybe ignored; but the decrease in hemoglobin is extraordinary, sometimes falling as low as 30 per cent, of the normal or below it, the color index often being as low as 0.5. The red corpuscles are, however, in severe cases irregular in form — that is, there is more or less poikilocytosis, and many of them may be undersized.


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