Publications of Cornell University Medical College: Studies From ..., volume 8
Publications of Cornell University Medical College: Studies From ..., volume 8
Cornell University. Medical College. Dept of Pathology
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The normal thyroid gland differs sharply from other normal glands, such as the liver or kidney, in having a large proteid content which forms no part of a living cell, so that the cell nuclei furnish only a relatively small amount of the proteid in a saline extract. With some of the pathologic glands nuclei are as abundant as they are in liver or kidney and the acetic acid precipitate contains more phosphorus than is obtained from normal gland extract, while the iodin containing globulin pre- c...ipitated by half saturating with ammonium sulphate is relatively scanty. It is to be expected that proteids having such chemical differences would show differences in therapeutic action. The dose of these pure proteids is very small. We rarely use more than 15 minims of a 1 to 1,000 solu- tion at a single dose, an amount corresponding to the dose of adrenalin. We have been able to get satisfactory therapeutic results with less dis- turbance of the heart and nervous system by the use of the proteids isolated in this fashion than we have by the use of the commercial 18.
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