Some Problems of Intermediary Metabolism
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made in our laboratory with sulphonal, a typical hepatic drug, tend to -how that in fasting dogs there is no undue formation of allantoin when soluble urates are injected into the circula- tion, !. e.f the normal uric acid oxidation is not interfered with, even though the animal be strongly under the in- * Mendel and Jackson: American Journal of Physiology, Vol. I, p.
■(• Mendel and White: On the Intermediary Metabolism of the Purin Production of Allantoin in the Animal Body. American Journal o...f Physiology, Vol. 12, p. 93.
26 SOME PROBLEMS OF fluence of the drug. When, however, animals fed on pan- creas, i. e., with an abundance of nucleoproteid, are treated with sulphonal, then it is found that allantoin, which on the above diet would normally appear in large amounts, is never present in the urine. Presumably, the sulphonal in some way iufluences favorably the oxidation of the purin compounds to uric acid and urea, and it is reasonable to assume that this action is due to some stimulating influence upon the oxidases of the liver or other glands, as to ascribe it to any other more general cause.
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To quickly assess the difficulty of the text, read a short excerpt:
made in our laboratory with sulphonal, a typical hepatic drug, tend to -how that in fasting dogs there is no undue formation of allantoin when soluble urates are injected into the circula- tion, !. e.f the normal uric acid oxidation is not interfered with, even though the animal be strongly under the in- * Mendel and Jackson: American Journal of Physiology, Vol. I, p.
■(• Mendel and White: On the Intermediary Metabolism of the Purin Production of Allantoin in the Animal Body. American Journal o...f Physiology, Vol. 12, p. 93.
26 SOME PROBLEMS OF fluence of the drug. When, however, animals fed on pan- creas, i. e., with an abundance of nucleoproteid, are treated with sulphonal, then it is found that allantoin, which on the above diet would normally appear in large amounts, is never present in the urine. Presumably, the sulphonal in some way iufluences favorably the oxidation of the purin compounds to uric acid and urea, and it is reasonable to assume that this action is due to some stimulating influence upon the oxidases of the liver or other glands, as to ascribe it to any other more general cause.
What to read after Some Problems of Intermediary Metabolism?
You can find similar books in the "Read Also" column, or choose other free books by Chittenden, R. H. (Russell Henry), 1856-1943 to read onlineMoreLess
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