Special Scientific Report--Wildlife 146

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28 In the body sodium monofluoroacetate, like other monofluoroacetates, is metabolized to highly toxic fluorocitrate. Fluorocitrate blocks the Krebs cycle, the major mechanism for releasing energy from food. The resulting buildup of citrate blocks glucose metabolism, another mechanism for releasing energy from food. The blockage of these processes causes the energy supply to be reduced to a point where cellular permeability barriers are destroyed, resulting in loss of function and finally cellu
...lar death. Eventually gross organ or organ system disorders are manifested.
Deaths results from cardiac and/or central nervous system failure.
Animals can metabolize sodium monofluoroacetate to non-toxic metabo- lites and can excrete monofluoroacetate as well as its toxic metabolite fluorocitrate. Tests with rats administered 5.00 mg/kg of sodium mono- fluoroacetate show that they excreted in the urine up to 32 percent of the amount prior to death, with non-toxic metabolites constituting 73 percent of the amount excreted.


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