Studies in Immunity

Cover Studies in Immunity
Studies in Immunity
Ehrlich Paul
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375 junctiva in man and animals. I have shown, furthermore, that it is possible, by means of conjunctival instillations, to actively immu- nize rabbits against abrin. Romer immunized a rabbit by means of rapidly increased doses into the right eye and killed the animal at the end of three weeks. It was then found that the conjunctiva of the right eye which had been the site of the inflammatory process was able, when ground up with a suitable amount of abrin, almost completely to neutralize the a...ction of this poison, whereas the other conjunctiva, when similarly ground up with abrin, was unable to protect the animal from death. From this Romer rightly concludes that in this conjunctival immunization part of the antitoxin is fur- nished by the conjunctiva which reacts locally. Aside from its theoretical interest I believe that this demonstration of the local origin of antitoxin at the site of injection possesses great practical significance. In certain cases the possibility is thus given to trans- fer part of the antitoxin production from the vital organs to the in- different connective tissues.

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