Studies in Immunity

Cover Studies in Immunity
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It must be admitted that both of these interpretations are purely hypothetical and have been sanctioned by no well-proved fact. We should then find out how far either of these hypotheses conforms with reahty by determining how far deductions from them agree with experimental fact.
Let us consider a fresh hemolytic serum containing both alexin and sensitizer. According to Ehrlich and Morgenroth, this sen- sitizer is combined with alexin — if not with all of it, owing to its possible excess, at l
...east with a more or less considerable amount of it. When corpuscles are added the sensitizer unites with them, dragging after it the alexin fixed by its other pole. The amount of alexin that can affect the corpuscles must be only that portion previously fixed by the sensitizer. If there is more alexin in the serum than is necessary to saturate the sensitizer, the excess could have no effect on the corpuscles and would consequently not be utihzed. We may therefore conclude that the added corpuscles are unable to modify in the slightest degree the established relations between alexin and sensitizer; they simply fix the sensitizer and are destroyed by the alexin already united with this intermediary body.

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