Technical Drug Studies By the Division of Drugs Examination of Hydrogen Dioxid
Technical Drug Studies By the Division of Drugs Examination of Hydrogen Dioxid
A W Arvill Wayne Bitting
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The results of this work undoubtedly show that acetanilid retards the deterioration of hydrogen peroxid solutions. The inhibition, however, is not uniform. For example, of two samples of hydrogen 22 TECHNICAL DRUG STUDIES. peroxid, made by the same firm and both containing acetanilid, one will deteriorate rapidly, while the other is fairly stable. The cause of such apparent abnormalities has not yet been determined. There are probably numerous contributing factors, but one undoubtedly is the di...fference in the methods of manufacture. Furthermore, the absence of acetanilid from a number of brands and their slow rate of deterioration shows that acetanilid is not necessary to prevent or retard decomposition. Hydrogen peroxid solutions containing acet- anilid sooner or later develop a yellowish or brownish tint and an odor resembling nitrobenzol. To what extent the presence of nitro- benzol and similar agents are objectionable has not been established. The Pharmacopoeia neither recognizes nor prohibits the use of acetanilid as a preservative or antiseptic or otherwise, yet many packages bear labels declaring the presence of acetanilid and at the same time designate the article to be the pharmacopceial product, an obvious inconsistency.
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