The Bacteriology of Whooping Cough a Dissertation Submitted to the Faculty of
The Bacteriology of Whooping Cough a Dissertation Submitted to the Faculty of
David J David John Davis
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, 1901, 51, p. 850 22 DAVID J. DAVIS are very numerous. But few polynuclear leucocytes are present, and these are usually filled with the bacteria. If the exudate of an animal inoculated with an amount insufficient to kill in 24 hours is examined about the second or third day, a very different picture is presented. The exudate is purulent and contains flakes of fibrin. The polynu- clear leucocytes are very abundant, and are busily engaged ingesting the bacteria. There are also present, in less ...numbers, large mononu- clear cells. These cells often contain one or more polynuclear leucocytes filled with bacilli. The ingested leucocytes may be seen in various stages of intracellular digestion, some being nearly perfect, while others show nothing but fragments of the nucleus. A number of animal experiments were made to determine the effect of introducing another organism with the influenza-like bacilli into the peritoneal cavity. This had been done with the influenza bacillus and the streptococcus by Jacobson, who found that the virulence of the bacilli could thus be increased so that much smaller doses of the bacilli alone would be sufficient to kill.
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