The Cerebrospinal Fluid

Cover The Cerebrospinal Fluid
The Cerebrospinal Fluid
Weed, Lewis H. (Lewis Hill), 1886-1952
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Pettit and Girard (55) immediately confirmed and extended these experimental findings of Cappelletti, including in their studies histologi- cal examination of the choroid plexuses. And Meek's (49) observations were likewise entirely confirmatory. The scope of the investigation was widened in 1913 by Dixon and Halliburton (19) who studied the effect of a large number of substances upon the rate of outflow of cere- brospinal fluid from an occipito-atlantoid cannula. They were able to classify the
... substances into four groups according to their effect on this rate of outflow, placing the volatile anesthetics, alcohol, carbon dioxide and extracts of choroid plexus and of brain in the group which caused marked increase in secretion. Slight increases in the outflow were found to be caused by large injections of water or of normal saline, cholesterin, kephalin, atropine, pilocarpine and amyl nitrite. In the large third group of substances which caused no increase or a diminution of secre- tion were included extracts of the pituitary, of mussel, of pineal and of pia mater, glucose, urea, lecithin, etc.

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