The Conduction of the Nervous Impulse

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, " xlii. P. 495, 1911.
INCOMPLETE RECOVERY AFTER CONDUCTION 33 lation may cause some " excitation fatigue " in the region stimu- lated, and a current of moderate strength may cause a slight local depression of excitability, 1 but under ordinary conditions the refractory period must be due entirely to the passage of the first nervous impulse and not to the local after-effects of the first stimulating current.
We may conclude then that the passage of a nervous impulse brings about a condition in
... which the nerve is tempo- rarily unable to respond to a second stimulus. This inability to respond might be due to two distinct factors. The nerve might be in such a state that a second stimulus was unable to effect the local change required for setting up a nervous impulse, or it might be unable to conduct an impulse even if this had been set up. In other words, the defect might be one either of excitability or of conductivity. As we shall see, the activity of the nerve is modified in both directions, and the phenomena of the refractory period are due to the impairment and recovery of excitability and also of conductivity.

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