The Direct Action of Atropine Homatropine Hyoscine Hyoscyamine And Daturine

Henry G Henry Gustav Beyer

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Exp. XXVII. — March 4, 1886. Terrapin, 890 grms. Beef's blood and Ringer's saline (1 : 1). Canulas as usual. Venous pressure 6 c. M. Arterial pressure 16 c. M. Hyoscinized blood (a) 0. 03 : 100 c. C. ; (6) 0. 25 : 100 c. C. ; (c) 0. 5 : 100 of normal blood mixture.
Time Bate Work in c. C. Temp, p. M. Per mia. Per miu. Ceut.
3. 20 32 14 18° Under normiil blood mixture.
On hyoscinized blood {a).
On hyoscinized blood (5).
I hyoscinized blood (c).
Auricles largely distended ; contractions barely [p...erceptible.
Heart's action getting to be irregular Obser- [vations discontinued.
In Experiment XII. On the heart of the dog, hyoscine was used in the proportion of 1 grm. Of the drug dissolved in 4000 c. C. Of defibrinated calf's blood. The first observation with blood of this strength shows a decrease in the rate of 9 beats in 30 seconds, or 18 beats per minute, and a total decrease in the work done of 52 c. C. Per 30 seconds, or 104 c. C. Per minute. The maximum reduction of both rate and work was reached after hyoscinized blood had run through the heart three minutes.

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