The Elimination of Caffein An Experimental Study On Herbivora And Carnivora
The Elimination of Caffein An Experimental Study On Herbivora And Carnivora
United States Bureau of Chemistry
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It appears, therefore, from the findings of Rost that the rabbit eliminated the largest amount of caffem unchanged, Avhile in the cat and in man only mmimal quantities found their way into the urine. Although the amounts of caffein reported by Rost undoubtedly represent aU of the alkaloid eliminated by the Iddney, as in some instances the urine of five days was examined, there is no evidence of the purity of the product obtained, as neither the melting point nor other tests, chemical or ph^-sio...logical, were made to identify the substance. Rost (15) assumed that the repeated extraction with alcohol, chloroform, and sodium benzoate is bound to extract caffein only. Bongers (4) studied the ehmmation of caffem into the stomach; after the subcutaneous injection of 1.0 gram of caffem sodium sahcylate into a dog, the examination of the contents of the stomach proved negative. T\Tien the dose was increased to 1.5 grams and adminis- tered the same way the contents of the stomach obtamed half an hour later gave a distinct reaction for caffein by the method of Schwarzenbach.
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