The Nature Manner of Conveyance And Means of Prevention of Infantile Paralysis

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Indeed great variations or fluctua- tions are known to occur not only in the number of cases, but also in the death rate. The extremes are represented by the occasional instances of in- fantile paralysis known in every considerable com- munity and from which no extension takes place, and the instances in which in a few days or weeks the number of cases rises by leaps and bounds into the hundreds, and the death rate reaches 20 per cent, or more of those attacked. While all the factors which dete...rmine this discrepancy are not known, certain of them have become apparent. A factor of high importance is the infective power or potency, or, technically stated, th e viru lence, of the microorganism or virus causing the disease. This virus is subject to fluctuations of intensity 8 which can best be illustrated by an example. The virus as ordinarily present in human beings even during severe epidemics has low infective power for monkeys. But by passing it from monkey to monkey, it tends to acquire after a variable num- ber of such passages an incredible activity.

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