The Nature of Enzyme Action

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Thrombozyme is a proteo- lytic enzyme, the process of coagulation being the first stage of its action, while the well-known fibrinolysis is the second stage. This brief statement gives but a mere abstract of this important work which is, in the main, a confirmation and extension of that of Wool- dridge. For further details the original papers must be consulted.
The work of Rettger on this question [1909] is also of much importance. He shows that " fibrin-ferment " is not destroyed by heat, and
...that it enters quantitatively into the products of the reaction. It is therefore not an enzyme. Further discussion of the subject does not, for this reason, fall within the scope of this monograph, nothwith- standing its intrinsic importance.
'With respect to the properties of tissue-extracts, the paper of Pekelharing [igo8] should be consulted.
i64 THE NATURE OF ENZYME ACTION Alcoholic Fermentation.
Finally, under the heading of this chapter may be mentioned those fairly numerous cases where more than one enzyme is requisite to effect a particular change.


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