The Organs of Internal Secretion : Their Diseases And Therapeutic Application, With a Chapter On Obesity And Its Treatment

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Opinion is divided as to the THE ADEENAL GLANDS 127 beneficial effects which result from the adroinistration of adrenalin to patients suffering from gross deficiency of this hormone — i.e., Addison's disease. 'Thus, Elliott says: " Neither with animal experiments nor in man has treatment with adrenalin been proved to be of value in prolonging Hfe. I have used hypodermic and intravenous injections of adrenalin without obvious benefit. Still, the substance is worth a trial." On the other hand, Ha...rrower says: "Addison's disease was naturally fijst among the disorders in which this form of treatment was tried; and while the results have been by no means uniform, numerous cases are recorded by such men as OHver, Langlois, Osier, Eobin, and others, in which the general condition was improved, pigmentation was diminished, and nutrition was bene- fited. In most cases the results were temporary, though Beclere obtained a complete and permanent cure in one case. He credits the treatment with causing a compensatory hypertrophy of the un- affected areas of adrenal tissue."® Again, it has been suggested that in some cases the causation is solely referable to the adrenal glands, while in others the sympathetic system is at fault, with or without adrenal disturbance; and that in the first class of case benefit is to be expected from adrenal therapy, while in the second we cannot and do not see improvement from the administration of the hormone.

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