The Pathology of Spavin ..

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In the cells near the surface the nuclei were nearly gone. They became larger as they approached the bone, and near the zone of calcification they appeared nearly normal. This process was produced experimentally by Cresswell in 1895 by means of long maceration and with the aid of pressure. He claims that chemically these fibrils are similar to connective tissue fibers.
Necrosis of the articular cartilage appeared in the form of diffuse superficial necrosis and as circumscribed areas within the
...articular cartilage. This was manifested by a disappear- ance of the nuclei and a pinkish staining matrix. It was seen in the early stages in which there was a reaction to a more severe irritation. Superficial necrosis in the form of crateriform erosions was more common. In these the carti- lage had disappeared. In some of the cases the remains of the cartilage were in the form of a gelatinous mass. In others part of the cartilage was gone and the remainder was pinkish and homogeneous. In still others the cartilage was entirely gone, having been apparently liquefied and absorbed.

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